منابع مشابه
Mito-communications.
It has long been known that the mitochondrial genome normally mutates at a higher rate than the nuclear genome. Direct estimates of mitochondrial mutation rates can be made by sequencing individuals from mutation-accumulation lines, for which the evolutionary timescale is known exactly. Using such an approach, estimates of mutation rates have been made for a small number of species (e.g. Denver...
متن کاملMito-nuclear Incompatibilities and Mitochondrial Replacement Therapy
Mitochondrial replacement therapy (MRT) is a human reproductive technology by which the mitochondria of a recipient’s eggs are effectively replaced by those of a donor, potentially eliminating harmful mitochondrial mutations carried by the recipient. However, concerns have been raised that MRT may lead to problems due to incompatibilities between the nuclear genome of the recipient and mitochon...
متن کاملIdentification of animal species images based on mito- chondrial DNA
The appearance of an animal species is a complex phenotype partially encoded in its genome. Previous work on linking genotype to visually-identifiable phenotypes has focused on univariate or low-dimensional traits such as eye color1, principal variations in skeletal structure2 and height3, as well as on the discovery of specific genes that contribute to these traits. Here, we go beyond single t...
متن کاملmito-QC illuminates mitophagy and mitochondrial architecture in vivo
Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if and how mitophagy proceeds within specific cellular subtypes in vivo remains unclear, largely because of a lack of tractable tools and models. To address this, we have developed "mito-QC," a transgenic mouse with a pH-sensit...
متن کاملMito-priming as a method to engineer Bcl-2 addiction.
Most apoptotic stimuli require mitochondrial outer membrane permeabilization (MOMP) in order to execute cell death. As such, MOMP is subject to tight control by Bcl-2 family proteins. We have developed a powerful new technique to investigate Bcl-2-mediated regulation of MOMP. This method, called mito-priming, uses co-expression of pro- and anti-apoptotic Bcl-2 proteins to engineer Bcl-2 addicti...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1711rr5